Abstract 11.2.4



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Histological Effects of Artesunate Administration on The Kidney of Wistar Rats


Okolie, N.J.C.

Department of Medical Laboratory Science, Imo State University Owerri


Abstract: Adverse effects on vital mammalian organs due to overdose of anti-malarials have been documented. Even under dose of the drugs to uninfected mammalian hosts could lead to deleterious effects on the organs or tissues. In the present work, a total of twelve wistar rats comprising of three groups (each group consisting of four rats) with uncertain infection status were given 25%, 50% and 75% of LD50 of artesunate by oral compulsion for a period of seven days. The animals were eventually sacrificed; their kidneys removed and processed by the conventional histological methods, stained with haematoxylin and eosin and examined microscopically. Mild, moderate and severe tissue proliferation, congestion and close adherence of the glomerula to Bowmanís capsules were progressively observed in each set of three groups with ascending concentration of artesunate. The study suggests that intake of artesunate adjured to be effective newer antimalarial without a corresponding presence of an infection could lead to mild, moderate and severe histological abnormalities of the kidney Avoidance of self-medication is recommended.


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