Abstract 11.2.6
 

 

 

Home Up

OSMOLAR CHANGES IN PREGNANT ALBINO WISTAR RATS

 

FREDDY .O. AGOREYO AND MARTHA .O. IZEVBIZUA.

 

Abstract: Pregnancy is associated with so many physiological changes including changes in the cardiovascular system, renal system and many others, and this has lead to the reason for this research. To investigate changes in plasma osmolality during pregnancy in rat and to investigate the changes in plasma sodium, plasma glucose and blood urea nitrogen concentration during pregnancy in rat. Materials and method: 20 female albino wistar rats were used. They were divided into two main groups: non pregnant control (n=5) and pregnant group (n=15). The pregnant group was further divided into three groups: first trimester (n=5), second trimester (n=5), and the last trimester (n=5). The rats were dehydrated for 18hrs and blood samples were collected. Plasma osmolality was calculated using the formula; plasma osmolality = 2. PNa+  + Pglu/18 + BUN/2.8 (mOsmo/kg H2O) (1). The result shows that the concentration of plasma osmolality in the last trimester of pregnancy (294.282.47mOsmo/kg H2O) was significantly lower than that of the control group (318.341.36 mOsmo/kg H2O) and the other two trimesters of pregnancy. Also, the mean Na+ concentration followed the same trend as that of the plasma osmolality. The mean value for BUN concentration of the pregnant rats compared with control did not achieve statistical significance. Also the plasma glucose concentration of the control group was higher than of the first and last trimester of pregnancy, but lower than that of the second trimester of pregnancy. This confirms that plasma osmolality decreases during pregnancy especially during the last trimester of pregnancy. Also, the plasma Na+ concentration was found to decrease. This is expected as Na+ is the major determinant of plasma osmolality.

 

Keywords: Plasma osmolality, sodium, BUN, pregnancy

 

For purchase of full article, send emails to:-    info@maryslessorjournalofmedicine.org   
 

 

Home ] Up ]

Send mail to Seniormaster@maryslessorjournalofmedicine.org with questions or comments about this web site.
Copyright Mary Slessor Journal of Medicine, 2012 
Powered by CYBERMED GOLD
Last modified: 12/28/12