Abstract 11.2.9
 

 

 

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Supplementation with Antioxidants Vitamins C and E Positively Modulate and Protect against Dihydroartemisinin Induced Haematotoxicity in Wistar Albino Rats

 

O.E. Mesembe*, G.U. Udoaffah, Olaitan R. Asuquo, V.S. Ekam1, C.C. Mfem2,

N.N. Kalu3 and A.O. Igiri

Department of Human Anatomy, University of Calabar, Nigeria

1Department of Biochemistry, University of Calabar, Nigeria

2Department of Physiology, University of Calabar, Nigeria

3Department of Pharmacology, University of Calabar, Nigeria

 

Abstract: The effect of vitamins C and E supplementation during dihydroartemisinin administration on some haematological indices of wistar rats was carried out. Thirty two adult albino wistar rats weighing between 180-260g were used. They were divided into four groups of eight rats each. Group A served as the control and were administered distilled water. Groups B, C and D were the experimental groups and were given cotecxin, cotecxin & vitamin C and cotecxin & vitamin E respectively for two weeks. The animals were weighed before the beginning and at the end of the experiment, and water and feed were allowed ad libitum. The packed cell volume of group B (42.88 3.65%) was significantly (p<0.05) lower than that of the control (group A) (48.70 2.26%); whereas that of the cotecxin + vitamin E group (group D) (48.52 3.28%) and cotecxin + vitamin C group (group C) (48 4.24%) were significantly (p<0.05) higher than that of the cotecxin group (group B). The haemoglobin concentration of cotecxin group (group B) (14.67 + 1.05g/dl) was significantly (p<0.05) higher than that of the control group (group A) (12.24 0.24g/dl). The haemoglobin concentration of the cotecxin + vitamin C group (group C) (12.49 0.66g/dl) and cotecxin + vitamin E group (group D) (12.58 1.06) were significantly (p<0.05) lower than that of the cotecxin group (group D). The red blood cell count of cotecxin group (group B) (3.46 x 106  0.26 x 106 cells per mm3 of blood) were significantly (p<0.05) lower than that of the control group (group A) (5.10 x 106  0.13 x 106 cells per mm3 of blood). The red blood cell of count of cotecxin & vitamin C group (group C) (4.99 x 106  0.20 x 106 cells per mm3 of blood) and cotecxin and vitamin E group (group D) (5.01 x 106  0.18 x 106 per mm3 of blood) were significantly (p<0.05) higher than that of the cotecxin group (group B). The white blood cell count of the cotecxin group (group B) (3.19 x 103  0.58 x 103 per mm3 of blood), as well as that of the cotecxin & vitamin C group (group C) (2.36 x 103  0.10 x 103 per mm3 of blood) were significantly lower than that of the cotecxin group (group B). The results suggest that cotecxin is haematotoxic in albino wistar rats, and that antioxidant vitamins C and E supplementation can ameliorate these effects.

 

Keywords: Wistar Rats; RBC; WBC; Dihydroartemisinin; Vitamins C and E

 

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