Abstract 11.1.9



Association Between Intermittent Preventive Treatment of Malaria in Pregnancy and Perinatal Outcome among Parturient in the University of Calabar Teaching Hospital, Calabar, Nigeria. 



C.U. Iklaki, J.E. Ekabua, A.E. Udo, T.U Agan and E.I Ekanem

Department of Obstetrics & Gynaecology University of Calabar, Calabar. Nigeria



Abstract: Intermittent preventive treatment with suphadoxine-pyrimethamine is recommended as part of the malaria control strategy in pregnancy in the tropics. This study set out to determine any association between the use of this regimen and preterm birth, low birth weight and fetal infection among parturients in Calabar. Pregnant women were assigned to the treatment and control groups. At delivery, the gestational age, placental parasitaemia, cord parasitaemia and birth weight were measured and the data analysed. There was no significant difference in placental parasitaemia between IPT treated and the control group, 10.6% and 11.3% respectively (p=0.76) A minority (7.9%) of IPT treated women had moderate to severe degree of placental parasitaemai as against 53.2% of women in the control (p=0.000) Preterm delivery was commoner among parturients in the control group, 20.6% as against 7.5%. (p=0.000) Infants born to women in the control group exhibited a higher incidence of low birth weight (8.9%) when compared to infants of mothers in the treatment group (2.8%) (p=0.003) There was a weak negative correlation between placental parasitaemia; gestational age (r=-0.10) and birth weight (r=-0.20). The association between placental parasitaemia and cord parasitaemia exhibited a weakly positive correlation, (r=0.20). Although intermittent preventive treatment of malaria in pregnancy did not eradicate placental malaria and did not prevent fetal infection in the treatment group, its use was associated with significant reduction in placental parasitaemia and reduced incidence of preterm birth and low birth weight infants among parturients in Calabar.


Keywords: Intermittent, preventive, treatment, malaria, perinatal, outcome.


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