Abstract 3.11




The Activities of NADH-MethB Reductase and Glucose - 6 - Phosphate
Dehydrogenase (G-6-Pd) in the Red Cells of Malaria Patients

E. Uko, A. Udoh, M. Etukudoh 
1Department of Haematology,Pathology College of Medical Sciences, University of Calabar, Calabar Nigeria 
Chemical Pathology College of Medical Sciences, University of Calabar, Calabar Nigeria







The activities of NADH-MetHB reductase and G-6-PD were investigated in malaria patients in Calabar, Nigeria. Seventy malaria patients were selected for this study. Sixty two age, sex matched apparently healthy children were used as controls. Ages of subjects ranged from 6 months to 12 years (mean = 5+ 1.3 years). Blood samples were collected from the patients before the commencement of treatment. The controls were confirmed to be malaria parasite negative. Blood samples were examined for the presence and type of malaria parasite. Plasmodium falciparum was the commonest infection encountered. NADH-MetHB reductase activity in malaria patients was 46% of the activity in controls. This indicates a lower enzyme activity in malaria patients than in controls (p


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