The effect of oral administration of crude extract of Rothmannia
hispida on alloxan
induced diabetic rats was studied to valuate the claimed
antidiabetogenic effects of the herb on the early symptoms of diabetes
mellitus. Twenty albino rats of wistar strain weighing 130-180g were
used. Thirteen of these were made diabetic by intraperitoneal injection
of alloxan. Administration of the herb extract in a dose of 0.36g/100g
body weight commenced after 1 week of untreated diabetes and lasted for
seven days. The results showed that treatment with R.
reduced plasma glycose from 27.53 ± 2.46 mmol/L in untreated diabetic
animals to 13.10 ± 1.84 mmol/L after treatment, (p
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