Abstract 6.  (1)2



Glucose-6-Phosphate Dehydrogenase and Malaria


C. J. Udiong1, T. J. Yinah2, and P. C. Inyang-Etoh3


1 Chemical Pathology Department, University of Calabar, Calabar, Nigeria

2 Schools of Medical Laboratory Science, UCTH, Calabar, Nigeria

3 Department of Medical Microbiology & Parasitology

University of Calabar, Calabar, Nigeria


Abstract: One hundred and forty eight subjects were screened for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and malaria parasites using the methaemogglobin reduction method and microscopic examination of Giemas stained thick and thin blood film respectively. An overall deficiency of 10.8% (female 2.7%, male 8.1%) was observed. Eighty sixth percent (86%) were normal and 2.7% heterozygous. All the heterozygotes were female. The mean G-6-PD levels for malaria infected people in the various groups were: asymptomatic 13.54.9/gHb, symptomatic 15.93.2U/gHb, asymptomatic male 13.935.09U/gHb, and asymptomatic female 15.853.11/gHb. There was a positive correlation between G-6-PD activity and malaria parasite density in symptomatic subjects (r = 0.593, p < 0.05) while similar analysis in asymptomatic subjects did not show a significant positive correlation. There was also a positive and significant correlation between G-6-PD activity and malaria parasite density among male subjects examined (r = 0.59, p<0.05). A similar analysis among female subjects examined showed no significant correlation (r = 0.30, p>0.05). There was a significant difference between the G-6-PD activity and malaria parasite density in symptomatic malaria subjects (P < 0.05) but no significant difference in asymptomatic malaria subjects and the control subjects. The G-6-PD activity and parasite density in male subjects was higher in symptomatic males but not in asymptomatic subjects (males and females). This result supports the hypothesis that G-6-PD deficiency may conger a selective protection in a malaria endemic area, as heterozygote subjects may be less susceptible to malaria.

Key words: Glucose-6-phosphate dehydrogenase activity, Malaria parasite, Selective Protection


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