Abstract 6.  (1)6
 

 

 

Malaria Parasitaemia in Diabetics in Calabar, Nigeria

 

C. J. Udiong1, M. A. Obu2, P. C. Inyang-Etoh3 and I. K. Isong1

 

1 Chemical Pathology Department, University of Calabar, Calabar, Nigeria

2 Schools of Medical Laboratory Sciences, UCTH Calabar, Nigeria

3 Department of Medical Microbiology & Parasitology

University of Calabar, Calabar, Nigeria.

 

 

 Abstract: Malaria parasite multiplication is an intracellular process and involves the use of host glucose as its source of energy. In poorly controlled diabetics though the peripheral blood glucose level is high the intracellular glucose level is low. This study was conducted to establish a relationship between malaria parasitaemia and the blood glucose level in diabetic patients in Calabar. The blood samples of 100 subjects were studied. 50 were diabetic patients attending diabetic clinic of University of Calabar Teaching Hospital and 50 were non diabetic apparently healthy individuals (control) of the same age range (30-65 years). Fasting plasma glucose concentration and parasite density were determined on both diabetics and non diabetics. The means and standard deviation of fasting plasma glucose concentration obtained from diabetics and non diabetics were 10.6+4.9 mmol/l and 4.4 + 0.9 mmol/l respectively. The parasite density of diabetics and non diabetics were 92.3+48.3 parasite/Ál and 147.6+91.9 parasiteÁl respectively. The percentile malaria positive of the diabetics and non diabetics were 32% and 54% respectively. Comparison of fasting plasma glucose concentration of the diabetics and non diabetics showed a significant difference correlation analysis between fasting plasma glucose concentration and parasite density of the diabetics and non diabetics did not show any significant relationship. The study shows that diabetic subjects are less susceptible to malaria parasitaemia than the non diabetic subjects probably due to their lower intracellular concentration of glucose.

Key words: Diabetes, Malaria, Susceptibility.

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