The effect of administration of chloroquine
on lipid deposition was studied in intracranial visual relay centers. Adult
Wistar rats (38) weighing averagely 200g were randomly assigned into
treatment (28) and control (10) groups. The rats in the treatment groups
received 2mg/kg body weight of chloroquine phosphate in distilled water for
13 days. The rats were sacrificed on days 1,3,5,7,9,11 and 13. The lateral
geniculate body and the superior colliculus were dissected out and frozen.
Frozen sections were stained with Sudan Black B. Results obtained showed
that prolonged administration of
chloroquine caused increased and diffused lipid deposition in these tissues
especially on the 13th day treatment group. This lipid deposition may
interfere with the normal functions of these visual relay centers.