article 10. 6
 

 

 

The Effect of Acute and Chronic Consumption of Fresh and Thermoxidized Palm Oil on Total and Differential White Blood Cell Count

 

Obembe, A.O.,

Department of Physiology,

College of Medical Sciences

University of Calabar, Calabar

 

 Okwari, O.O

Department of Physiology,

College of Medical Sciences

University of Calabar, Calabar

 

Ofem, O. E.

Department of Physiology,

College of Medical Sciences

University of Calabar, Calabar

 

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Abstract

Abstract:  The effects of acute and chronic feeding on fresh and thermally oxidized palm oil diets on total and differential white blood cells were studied. Sixty albino Wistar rats were randomly assigned into 2 batches of 30 rats each, for acute and chronic feeding studies. Each batch was further subdivided into 3 groups of ten rats each and was fed on either normal rat chow, fresh palm oil (FPO) or thermoxidized palm oil (TPO) diets. The acute and chronic feeding lasted for 4 and 12 weeks respectively. Results obtained revealed that the total white blood cell (TWBC) counts for control, FPO and TPO for acute study were 6.40 0.36, 6.60 0.56 and 12.00 0.59 x 103 cell/mm3 respectively, while the TWBC count for the chronic study were 8.60 0.62, 14.70 0.61 and 8.90 0.53 x 103 cell/mm3 for control, FPO and TPO respectively. Results showed that total WBC was increased following both acute consumption of TPO and chronic consumption of FPO. The increase in total WBC count following acute consumption of TPO was probably due to increase in basophils, eosinophils and lymphocytes which were observed to be significantly higher in TPO than in other groups. Increase in primarily the basophils and to lesser extent lymphocytes was responsible for the increase in total WBC count following chronic consumption of FPO diet. The reduction in lymphocyte count following chronic consumption of TPO diet suggests destruction of the lymphocytes probably by toxicants released into the blood after prolonged exposure. In conclusion, acute consumption of TPO increases total WBC count, on the other hand chronic consumption of FPO also increases total WBC in rats.

 

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